Exact(8)
These data support potent anti-myxovirus activity of the compound with active concentrations ranging from 10 to 80 nM depending on the target virus.
At this dose level, plasma AT7519 concentrations were above the biologically active concentrations, and preliminary anti-cancer activity was observed in patients.
Also, XR5944 does not inhibit the catalytic activity of topoisomerase I or II at active concentrations and does not significantly stimulate DNA scission mediated by either topoisomerase I or II unlike camptothecin or etoposide (Sappal et al, 2004).
The oral administration of the gum resin extracts of Indian frankincense (Boswellia serrata Roxb. ex Colebr) results in very low plasma concentrations of boswellic acids (BAs), being far below the pharmacologically active concentrations required in vitro for anti-inflammatory activity.
To achieve the high dopant activation needed to reduce contact and channel access resistances, active concentrations if possible above solid solubility are required.
Here, we report that XCT 790 potently activates AMP kinase (AMPK) in a dose-dependent and ERRα-independent manner, with active concentrations more than 25-fold below those typically used to perturb ERRα.
Merseyside has one of the largest and most active concentrations of Momentum members.
Moreover, release was relatively rapid with antimicrobially active concentrations being achieved by 2 4 h.
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