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It is useful, therefore, to have substances which can be administered to patients to prevent active complement activation.
It is useful, therefore, to have substances which can be administered to patients to prevent active complement activation thereby preventing autoimmune diseases from occurring [3, 23, 25].
injection, in which neutrophils can be activated in the absence of active complement [ 45].
Complement activation leads to the generation of biologically active complement peptide fragments such as C5a and C3a that elicit a number of pro-inflammatory effects 2, 8.
The deposition of active complement on fetal membranes was confirmed by immunohistochemistry. Women who underwent non-labor-indicated Cesarean sections did not exhibit complement deposition.
Active complement, as assessed by the C9 neo-antigen in C5b-9 complexes, was deposited on fetal membranes, with no difference between term and preterm delivery.
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In trout, carp, and seabream, these C3 isoforms exhibit different binding efficiencies to several active complements; as such, these isoforms may perform separate roles in the destruction of microbes and innate recognition [ 25].
However, no deposition of activated complement was seen in active cortical lesions at the site of active demyelination, as described before in MS. [ 9].
The early active lesion part was characterized by deposition of IgG and activated complement at the sites of ongoing demyelination.
Together, these findings suggest that the nuclear program of cells identifying themselves as "pluripotent" actively promotes a smaller and less active mitochondrial complement — presumably to minimize the potential for DNA damage from ROS — as suggested in the Introduction.
The more active the complement system, the more erythrocytes get lysed, i.e., less serum is needed to lyse 50% of a fixed amount of erythrocytes.
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