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Facing this pressure, institutions that systematically source and deploy collateral at minimum cost will reap the benefit of lower funding costs and, potentially, generate returns from active collateral trading.
The initially and only briefly ischemic lower leg in black mice [ 62] recovers fast due to the increase in collateral flow but also due to the decrease in metabolism [ 66] probably by hibernation and preconditioning causing the rapid restoration of tissue hemoglobin saturation at times of continuing active collateral growth [ 125].
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Although traditional life-history theory would suggest that an evolutionary tradeoff may be a result of limited resources between maintenance of the immune system and reproduction, we speculate from our results that it is more likely driven by direct costs of immunity, such as collateral damage from active antimicrobial activity.
Had collateral activity in the Web.
In the first case, we encountered infrarenal agenesis and azygos continuation of IVC with active superficial, deep, and portal collateral pathways (Fig. 1).
Friday's civilian casualty announcements leave Central Command with one more active investigation of a credible collateral-damage allegation, according to a briefing for reporters last week.
We could show, by in-vivo pulse-labeling with tritiated thymidine and uridine, that pre-existent coronary collaterals enlarge by active proliferation of endothelial cells which preceded that of SMCs after DNA and RNA synthesis [ 25, 102, 123].
Subsequent immunofluorescence analyses in remodelling collaterals by utilizing a specific antibody against (active) RhoA-GTP indicated that RhoA activation was more pronounced in SMCs of wild-type but not RGS5-deficient mice (Fig 5D).
This is in keeping with epidemiologic evidence that in patients with coronary artery disease, collateral function is better in more active individuals [ 8].
However, compounds 2 and 3 were generally less active towards resistant cancer cells, with 3 showing collateral sensitivity towards resistant breast adenocarcinoma MDA-MB-231/ BCRP cells (D.R.: <0.70 compared to its sensitive subline MDA-MB-231) [ 37].
Furthermore, internal collaterals of motor commands also modulate active sensory systems.
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