Most pituitary carcinomas are hormonally active; the predominance of non-hormonally active carcinomas in the oldest series is probably attributed to the lack of hormonal assays and routine use of immunohistochemistry[ 4 6].
The promoter regions were active in esophageal carcinoma (Additional file 5: Table S3), but the transcriptional activity may not be directly linked with the Ad-mediated cytotoxicity since multiple factors such as sensitivity to cell death are involved in the cytotoxicity.
The two compounds, selected as potential agents active against hepatocellular carcinoma (HCC) were then evaluated in vitro for their biological activity on HCC-derived cell lines.
These results demonstrated that positive regulatory sequence elements active in human carcinoma and fibroblast cells are concentrated within the region −219 to −43 of FSCN1.
To date, very little information exists about which LPA receptors are present and active in oral carcinoma cell lines.
Sunitinib has been found to be active against urothelial carcinoma (UC) both in vivo and in vitro and to enhance cisplatin activity (Sonpavde et al, 2009).
Given the extent of PDAC desmoplasia, CAF constitute a major component of the tumour-associated stroma and several previous studies have identified these cells as active interactors of carcinoma cells.
Temsirolimus is a rapamycin analog that is active against renal cell carcinoma, endometrial carcinoma, breast cancer, glioblastoma multiforme, and gastrointestinal neuroendocrine tumors.
Moreover, expression of Wnt target genes including FGF9 (fibroblast growth factor 9) has been described, suggesting that this pathway is active in endometrioid carcinomas [ 55– 55].
Upregulation of Magmas has been found in metabolically active tissues, various carcinomas and in tissues of different developmental stages, but the physiological relevance of such higher levels of the protein is still unknown.
