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As ALP is a byproduct of osteoblast activity, increased level of ALP refers to active bone formation.
Also, elevated ALP indicates that there could be active bone formation occurring as ALP is a byproduct of osteoblast activity (such as the case in Paget's disease of bone).
The GABA-treated group also showed evidence of active bone formation, and the ORZ-treated group showed an increase in osteoblastic activity and an increase in new bone formation.
The unmineralized matrix constitutes an osteoid seam or border, averaging 6 to 10 microns in thickness during active bone formation.
The combination of MSCs and LOG nanoparticles resulted in improved active bone formation and increased mineralization.
ALP is a by-product enzyme of active bone formation, which means its level increases when the bone matrix is being formed.
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After the bone graft, the experimental group showed an aspect of active new bone formation and grafted bone absorption and replacement by newly formed bones through substitution were observed.
Further down in the specimens, roughly halfway through the graft, a zone with active new bone formation was seen closely preceded by resorption of the graft.
It has been strongly suggested that silicon/silica is functionally active during bone formation with a close relationship between silicate and calcium deposition.
In addition, valvular interstitial cells may develop towards an osteoblastic phenotype taking part in active heterotopic bone formation within the valvular leaflet.
Consequently, unlike bones, enamel has no way to regenerate itself using the process of "active mineralization" (see bone formation) because there is no biological process that repairs degraded or damaged enamel (Avery 2001; Nanci 2012).
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