Compounds 8, 12, 14 and 17 proved to be the most active and efficacious candidate in this series, with mean GI50 values of 1.30 μM, 1.43 μM, 2.38 μM and 2.18 μM, respectively against several cancer cell lines.
Sharing control was about feeling they were an active and efficacious participant in the screening process.
As can be seen, the sample was low to moderately active, moderately efficacious, and with few disabilities.
With renewed calls for malaria eradication, next-generation antimalarials need be active against drug-resistant parasites and efficacious against both liver- and blood-stage infections.
To ensure continued malaria control, with an aim for eradication, next-generation antimalarials are required to be active against multidrug-resistant parasites and efficacious against liver- and blood-stage infections.
In aorta, the PPARβ/δ agonist, GW0742, was an active vaso-relaxant, but was less potent and efficacious than in pulmonary artery.
Structure-guided design of inhibitors of thrombin (factor IIa, fIIa) and factor Xa (fXa) eventually led to the discovery of potent, selective, efficacious, orally active and safe compounds that proved successful in clinical studies.
For simplicity they use the acronyms ACURE (Acute, Critical, Unexpected, Responsive, and Easily diagnosed and treated), CARE (Critical, Active, Recalcitrant, and Eventual), and COPE (Chronic, Outpatient, Palliative, and Efficacious).
Compound 9g, proved to be the most potent and efficacious derivative in this series, was orally active in an HCT116 xenograft model in vivo.
The primary aim is to examine whether therapist-assisted iCBT is an acceptable and efficacious treatment, as compared to an analogous active control, for patients who can choose to continue with their usual treatment.
It needs to be safe, valid, reliable, useful, and efficacious.
