Sentence examples for activator further from inspiring English sources

Data on supplemental use of 22-oxacalcitriol, Vitamin D receptor activator, further suggests improved bone formation due to antioxidative property of Vitamin D in diabetic bone disease [ 61].

Despite advances in high throughput screening efforts to discover HSF1 activators, further efforts are necessary to hone the response and selectivity of HSF1 activation by small molecules.

Since integrin cleavage is mediated by Urokinase-type Plasminogen Activator (uPA), further work is warranted to test the efficacy of uPA inhibitors for prevention or delay of cancer induced bone pain.

The activation of innate immune responses in the mucosa and the resulting inflammation serves as an activator of further innate immune responses.

Remarkably, overexpression of PPARα-tr in these cells not only reversed the effect of the PPARα activator, but further decreased viability on day 12 substantially below control levels (vector-transfected cells treated with WY14,643).

Efforts to obtain a single-crystal X-ray structure of 3 with or without PUGNAc were not successful, perhaps reflecting the poor aqueous solubility of 3 compared to the original activator 2. Further exploration of these compounds led to 4, 5, and 6 with a morpholino group at the R position.

In the case of CD2 1.3B transgenic mice, compaction of the enhancer (and promoter) might prevent the binding of trans-activators and further recruitment of activating chromatin modifiers making the hCD2 transgene more resistant to derepression.

Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization.

Altogether our data suggest a failure of mTOR activation by amino acids or ER stress activators to further upregulate GRP78 in the brain of PGC-1β KO mice.

These studies resulted in the discovery of a new scaffold for glucokinase activators and further exploration of this scaffold led to the identification of GKA60.

How z-LIG activates the Nrf2 pathway and whether it shares the same mechanisms of other Nrf2 activators need further investigation.