The analysis indicates that STAT3 primarily functions as a transcriptional activator whereas a subset of its binding might contribute to transcriptional repression, which is consistent with its roles as previously described (Ouyang et al. 2009).
The histone acetyltransferase PCAF functions as a transcriptional co-activator of a subset of NF-κB regulated genes [51], including cyclooxygenase-2 (COX-2) [52].
Importantly, it has been shown that BCL3 and IRF3 might play complementary roles as co-activators, at a subset of NF-κB targets, in TNF- and LPS-induced cells, respectively [ 5], which could mean that BCL3 can initiate chromatin remodeling.
ICG-001 inhibits the interaction of β-catenin with the histone acetyltransferase and transcriptional co-activator CBP, hence blocking transcriptional activation of a subset of β-catenin regulated genes.
Comparison of human and zebrafish PXRs for a wide range of possible activators revealed that zebrafish PXR is activated by a subset of human PXR agonists.
XBP1 gene, after a nonconventional splicing event [ 28], codes for a transcription activator that regulates a subset of ER-resident chaperones that are essential for protein folding, maturation and degradation in the ER [ 29].
One candidate pathway is that of STAT (signal transducer and activator of transcription) proteins, a subset of which are directly activated by EGFR independent of JAK signalling or bridging (David et al, 1996).
To further correlate DNA binding events to potential transcription activation or repression, a subset of CREB-bound promoters were analyzed using high-throughput reporter assays in the presence or absence of protein kinase A pathway activators as well as the CREB transcriptional co-activator, TORC1.
These phytochrome effects may be reminiscent of the activator-to-repressor conversion of a subset of Hd1 proteins that is observed under LD (see below; Izawa et al. [28]).
Thus, whereas Th17 signals recruit signal-transducer and activator of transcription protein (STAT 3/RORγt to a subset of NFAT/AP-1 binding sites, Th1 or Th2 signals recruit STAT1/T-bet or STAT6/GATA-3 totherer NFAT/AP-1 binding sites.
