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Since the extracellular sequences and structures of GPCRs are not conserved between receptor subfamilies, it is likely that the initial molecular triggers for activation vary depending on the specific type of ligand and receptor.
It is clear that the consequences of mTORC1 activation vary significantly in different cell lineages.
Although consensus exists that the amygdala again plays an important role in extinction, a closer look reveals that the details about amygdala activation vary.
The precise consequences of HIF activation vary between tumour types, with a balance between protumour and antitumour effects being manifest.
However, the consequences of p53 activation vary, ranging from cell death to cell survival, and are difficult to predict.
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Although any DSB discontinuity can activate DNA-PK, its activation varies considerably depending on the end structure, and studies show kinase activation in trans (achieved by kinase autophosphrylation) or cis (achieved by specific DNA strand orientation and sequence bias) [ 35].
However, details of patterns of activation varied across participants: subdivisions commonly activated during performance of the two tasks were the bilateral VLPFCs, either side of the VLPFC, and either side of the DLPFC in 4, 2, and 4 of the 12 participants, respectively.
Building upon improved understanding of the molecular and physical mechanics of lymphocyte activation, varied strategies for engineering surfaces to activate and deactivate T-Cells, B-Cells and natural killer cells are in preclinical and clinical development.
We also found that activation varied with task demands, with more extensive frontal activation noted in the overt compared to the covert verb inflection task.
Nevertheless, the contribution of SMA was not exclusively restricted to the preparation/initiation of verbal responses since the extension of mesiofrontal activation varied with task duration.
The Ca2+ concentration needed for half-maximal activation varied between 0.08 and 0.11 µM.
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CEO of Professional Science Editing for Scientists @ prosciediting.com