Sentence examples for activation to activate from inspiring English sources

Based on these results, we suggest that rVvhA stimulates ROS-mediated PKC activation to activate NF- κB-dependent signaling pathways via MAPKs in promoting INT-407 cell apoptosis.

IFNγ functions through activating the Jak-STAT signaling pathway, whereas LPS and TNFα induce NF-κB activation to activate iNOS transcription.

Procaspase-8 was not cleaved following Fas receptor activation and further investigation demonstrated that defective DISC formation was the underlying cause by which Fas receptor activation failed to activate either JNK or caspase-8.

Moreover, JunB functionally collaborates with NF-κB, a transcription factor with essential role in DC activation [34], to activate the CCR7 gene in this cell line.

LKB1 phosphorylates a critical threonine in this activation loop to activate AMPK.

Caspase-9 and caspase 3, which are downregulated upon PKB/Akt activation, fail to activate pathways leading to apoptosis [ 19].

By comparing Figure 2A and 2B, in which we run the simulation in the absence of SOCS3, we observe that the effect of SOCS3 expression in response to STAT3 activation is to activate the slow attenuation process observed in the full model: removal of SOCS3 suppresses the delayed re-appearance of cytoplasmic STAT3 and the pathway exhibits prolonged and stable nuclear occupancy of STAT3.

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As the intracytoplasmic domain lacks any signaling capacity, TREMs associate with a transmembrane adaptor protein, DNAX activation protein-12, to activate intracellular pathways, which include activation of phosphatidylinositol 3-kinase, the phosphorylation of phospholipase Cγ and extracellular signal-related kinase1/2, and an increase in intracellular calcium.

In monolayer culture, autocrine EGFR activation is necessary to activate AKT [ 30], so we determined whether autocrine EGFR activation is necessary for AKT activation in organotypic culture.