Similar(60)
The timeframe of activation of CG genes in developing germline cells is compatible with this proposed role of miR-767.
To assess whether NPD1 specifically targeted BIRC3 transcription, and to determine the timeframe of activation, a qPCR assay was run that tested BIRC1 through BIRC8 on ARPE-19 cells after 2, 4 and 6 h of OS treatment in the presence or absence of 100 nM of NPD1.
Induction of bmf was rapid following seizures, in the same timeframe as Bax activation in the CA3 subfield at mitochondria.
All of the cell lines we observed as sensitive to TMZ treatment were also correctly predicted by APOPTO-CELL to achieve appropriate levels of caspase-3 activation within the 60 min simulation timeframe, with a median time of 26 min to achieve 80% substrate cleavage.
The observed gene expression profiles were consistent with the activation of DNA repair mechanisms in the timeframe between 5 and 20 days.
The rate-limiting factor by this timeframe for additional c-Fos activation is not the c-Fos mRNA or protein, but the upstream kinase FRK.
Because cathepsins are known to activate other cathepsins as well as MMPs (Okada and Nakanishi, 1989), it is possible that the reduction observed was due to a block in the proteolytic activation of proteases by cathepsin K. Owing to the extended timeframe of the rescue experiments, however, it is also plausible that inhibition of cathepsin K activity reversed a broader pathogenic cascade.
In what timeframe?
Is there a timeframe?
What's your timeframe?
The answer depends on the timeframe.
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