Sentence examples for activation the development of from inspiring English sources

As inhibition of IKK-β is abolishing NF-κB activation, the development of small molecule IKK-β inhibitors as potential anti-inflammatory and chemosensitizing agents is promising.

This finding also extends previous evidence advocating a role of Egr-1 activation in the development of atherosclerosis and may suggest that Egr-1 activation may contribute to atherosclerosis through the downregulation of ApoE.

These results demonstrate a role for JNK activation in the development of cardiomyopathy caused by LMNA mutations.

Our goal was to test the predictive value of cognitive deficits and brain astrocyte activation for the development of epilepsy following a potential epileptogenic injury.

The only way to examine a clear causal role for immune activation in the development of a mood episode is to measure euthymic patients multiple times prior, during and after a mood episode.

The molecular mechanisms of AR activation in the development of a hyperactive GnRH pulse generator are not well defined.

A second opportunity for improving latency activation is the development of enhanced delivery vehicles for existing molecules.

MYC is amplified in up to 50% of HCC cases, suggesting a key role for MYC activation in the development of these tumors [32], [33], [34].

Non-specific inhibitors of the NFκB pathway, including aspirin and aspirin-related drugs, have shown positive therapeutic effects in diabetic patients, indicating the importance of NFκB activation in the development of type 2 diabetes [2], [6], [17], [18], [29].

Our in vitro studies provided further evidence that the detrimental effects of JEV-induced microglial activation on the development of NSPCs is via release of soluble inflammatory mediators from the activated microglia, which is reversed upon minocycline treatment.

The results indicate possible involvement of PFTK1 activation in the development of chemoresistance.