This finding also extends previous evidence advocating a role of Egr-1 activation in the development of atherosclerosis and may suggest that Egr-1 activation may contribute to atherosclerosis through the downregulation of ApoE.
Interestingly, the clinically available antidiabetic drug metformin, which is also a AMPK activator thus mTOR inhibitor (see above), prevents rapamycin-induced ERK activation and the development of mechanical hypersensitivity and spontaneous pain [ 79].
Assessing all patients with early arthritis, regardless of disease diagnosis, we found that each MAPK was more highly activated in patients with erosive disease, but here, only JNK activation predicted the development of erosive disease.
These results demonstrate a role for JNK activation in the development of cardiomyopathy caused by LMNA mutations.
Our goal was to test the predictive value of cognitive deficits and brain astrocyte activation for the development of epilepsy following a potential epileptogenic injury.
The only way to examine a clear causal role for immune activation in the development of a mood episode is to measure euthymic patients multiple times prior, during and after a mood episode.
The molecular mechanisms of AR activation in the development of a hyperactive GnRH pulse generator are not well defined.
A second opportunity for improving latency activation is the development of enhanced delivery vehicles for existing molecules.
MYC is amplified in up to 50% of HCC cases, suggesting a key role for MYC activation in the development of these tumors [32], [33], [34].
Non-specific inhibitors of the NFκB pathway, including aspirin and aspirin-related drugs, have shown positive therapeutic effects in diabetic patients, indicating the importance of NFκB activation in the development of type 2 diabetes [2], [6], [17], [18], [29].
