This method does not require an activation task; it can be used in anesthetized normal and in genetically modified and cognitively impaired mice.
Functional connectivity analyses and examination of correlations of connectivity strength with performance on the activation task as well as neurocognitive tasks completed outside of magnet were conducted.
Main Outcome Measures: fMRI was performed on a 3T ISOL Forte scanner with single-shot echoplanar imaging sequences before and after the intervention using a modified Posner paradigm as an activation task.
These findings demonstrate that visual complexity of websites has multiple effects on human cognition and emotion, including experienced pleasure and arousal, facial expression, autonomic nervous system activation, task performance, and memory.
Eleven participants, including one individual with severe physical disabilities, participated in a cued activation task in which the dual-switch exhibited sensitivities and specificities of 96.8 ± 3% and 98.4 ± 1%, respectively for vocalizations, and 99.7 ± 0.5% and 99.2 ± 0.5%, respectively for muscle contractions.
Hemoglobin concentration changes were measured during the activation task.
Moreover, previous studies did not evaluate data from both children-adolescents and adults using the same activation task.
The activation task consisted of a 30 sec rest, a 30 sec letter fluency task and 30 sec rest.
Previous NIRS studies showed that the verbal fluency test is a valid cognitive activation task to evaluate [Hb] change in prefrontal cortex using NIRS [14], [30], [31], [33], [40].
The cognitive activation task, which was described previously [21], [22], [28], included a 30-sec pretask baseline, a 60-sec verbal fluency task (letter version), and a 70-sec posttask baseline while sitting on a chair.
However, some important differences exist between that and our work: Baliki and collaborators' studied functional connectivity indirectly, extracting it from an activation task (i.e. attention fMRI paradigm); their patients suffered form back pain; their results were obtained from deactivations and seed voxel correlations.
