Exact(6)
Perhaps during prolonged H2O2 exposure, DNA damage accumulates and massive PARP-1 activation quickly depletes cellular NAD+ (a SIRT1 co-substrate), leading to decreased SIRT1 activity and necrotic cell death.
Elevators lifted by hoisting ropes are required to have platform "safeties," devices designed to clamp onto the steel guide rails upon activation, quickly braking the elevator to a halt.
The second argument is that it is administratively costly to scale the level of activation quickly up and down according to cyclical fluctuations.
The task of SHIP1 at the FcγRIIB is to "simply" stop cellular activation, quickly and completely.
The synchronized early transcriptional upregulation of MCL1 and its inhibitory interacting proteins PMAIP1 [ 24] and BMF [ 85] imply their involvement in T-cell activation quickly upon TCR ligation.
The difference between the two responses develops very early (as soon as the HNCs start to engage in the competitive process) and also peaks early (at around eight time-steps, as a word HNC stimulated in isolation reaches full activation quickly).
Similar(54)
In contrast, the MLC activation level quickly rises to high levels and rapidly decays to low levels after 50 min in the presence of thrombin + histamine, the signalling strength thus becomes less than additive after 50 min (Additional File 1, Figure S13, dash-dotted line ).
After activation, integrins quickly associate within the actin cytoskeleton and cluster together to form focal adhesions, multimolecular complexes that contain signaling molecules including focal adhesion kinase (FAK), paxillin and Erk1/2.
We made use of the fact that upon activation FSAP quickly forms stable covalent complexes with its plasma inhibitors.
These compounds release COS upon activation, which is quickly converted to H2S by the ubiquitous enzyme carbonic anhydrase (CA).
Full and complete esterification of oleic acid and methanol, catalyzed by cationic activation, is done quickly at room temperature in a new kind of reactor fitted with cation-exchange membranes, REMI This type of reactor displays liquid phases and prevents the occurrence of the compensating ion of the proton, which catalyses the reaction, in the reaction medium.
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