Exact(25)
For example, N-acetyl-L-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC), anti-oxidants commonly used in studies of NF-κB activation, prevented TNF induced NF-κB DNA binding independent of their antioxidant activity [ 25].
This is also consistent with studies showing that activation of MAPK activity resulted in the disruption of tight junctions, and that inhibition of MAPK activation prevented this process [ 47, 48].
Prenatal immune activation prevented the effects of environmental enrichment which increased exploratory behavior and microglia density in NaCl treated mice.
Inhibition of mTORC1 signaling attenuated the ER stress response and lipid accumulation induced by high glucose or by deletion of tuberous sclerosis 2. In addition, AMPK activation prevented the mTORC1 activation, ER stress response, and lipid accumulation.
In these cells, pharmacological inhibition of 5-LO activation prevented the dexamethasone-dependent increase of Aβ formation to a similar extent of a classical γ-secretase inhibitor.
We here demonstrate that blocking P-gp during DC-induced T cell activation prevented specific CD4+ and CD8+ T cell proliferation, which was accompanied by reduced secretion of proinflammatory cytokines TNF-α and IFN-γ.
Similar(35)
Nag S, Khan MA, Samuel P, Ali Q, Hussain T. Chronic angiotensin AT2R activation prevents high-fat diet-induced adiposity and obesity in female mice independent of estrogen.
The increased insulin-induced vasodilation during [alpha ]-adrenergic inhibition suggests that insulin-induced sympathetic activation prevents excess vasodilation.
Blockade of JAK pathway activation prevents increased PD-L1 expression resulting in increased susceptibility of tumor cells to NK cell activity.
A linkage to these representations in the ACC could be crucial to prevent premature responding during the working memory delay consistent with previous human and monkey results, suggesting that ACC activation prevents impulsive responding41,42.
Although, in principle, JAK-STAT signaling is relatively simple, the ambiguities in a receptor activation prevent a clear explanation of the underlying molecular mechanism.
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