This behavior could be explained by a model posing that at lower IPA concentrations, IPA occupies the ATP-binding sites of a subset of PERK molecules, triggering kinase activation of neighboring, unoccupied PERK molecules, as previously shown for other kinases (Hall-Jackson et al., 1999; Hatzivassiliou et al., 2010; Poulikakos et al., 2010).
In addition to providing practical analytical benefits by shifting signal to regions of unoccupied space, the low-energy activation experiment have provided insight into the structural heterogeneity of gas-phase proteins.
Another possible mechanism includes transient activation of p38 (Faust et al., 2012) by EGFR signalling that leads to acceleration of unoccupied receptor internalization (Zwang and Yarden, 2006; Faust et al., 2012).
We have millions of unoccupied homes in this country.
Crowd breaks widows of unoccupied squad near Sherman and Auer.
Following an example from Martin (1992), Nudds argues that while vision involves awareness of unoccupied locations, audition does not involve awareness of regions of space as empty or unoccupied.
The decline in Ae. aegypti populations was associated with Ae. albopictus infestation of unoccupied breeding sites.
If the assumptions in the present study are correct and endocytosis serves to maintain the endosomal pool of unoccupied EGFR in dephosphorylated state, the bulk of the receptor (located at the cell surface) would be capable of autonomous activation.
Rafting may, in contrast, enable long-distance dispersal and colonisation of unoccupied habitats.
In addition to controlling basal cAMP accumulation, targeting of PDE4D to the β1AR may prevent heterologous desensitization of unoccupied receptors.
