Sentence examples for activation of transgene expression from inspiring English sources

In this system, an intracellular signal that is specifically and abnormally activated in the diseased cells is used for the activation of transgene expression.

In this strategy, an intracellular signal that is specifically and abnormally activated in the target diseased cells is used for the activation of transgene expression [11, 12].

If such hyperactivated PKCα can be used for the activation of transgene expression, cancer cell-specific gene regulation becomes possible.

In the study reported here, we further demonstrated the transcriptional activation of transgene expression in association with the onset of cellular proliferation using the mouse partial hepatectomy model.

The UAS element is bound by Gal4, which results in activation of transgene expression.

Co-localisation of GFP and Cre immunoreactivity in the CA1 region of NEX-Cre mice suggests that activation of transgene expression depends on the Cre-mediated recombination of AAV genomes (Fig. 2).

The engineering of cell-specific enhancers to improve potency and the development of two-step transcriptional activation (TSTA) approaches have significantly improved the efficacy of transgene expression.

However, certain limitations apply to most of these systems, including leakiness of transgene expression, inefficient transgene silencing or activation, as well as limited tissue accessibility of transgene-inducers or their unfavourable pharmacokinetics.

Nevertheless, our study suggests that insertion of an insulator in gene therapy vectors might be associated with a cost in terms of level of transgene expression and might not block activation of all genes.

This NP which decorated with stearyl-conjugated KALA, an α-helical peptide (sequence WEAKLAKALAKALAKHLAKALAKALKACEA) showed enhancement of transgene expression; this enhancement was closely related to immune-activation [ 122].

Comparing the NF-κB response with magnitude of transgene expression (Figure 4B bottom panel) confirms the enhanced NF-κB activation of Casp8p41 compared to Casp8FL, observed in previous experiments using reporter constructs.