Sentence examples for activation of differentiation from inspiring English sources
Polyphenols exert their activity through several mechanisms: carcinogen detoxification, DNA repair, cell cycle progression, activation of differentiation, and epigenetic modulation.
The output of the specification process soon results in direct activation of differentiation gene batteries.
We also analyzed Barx2 expression during primary myotube formation; specifically Barx2 mRNA levels were measured by RT-PCR at different times after activation of differentiation by serum withdrawal.
We assumed that activation of differentiation in NT2 cells would require substantial epigenetic modulation, especially changes in PcG presence, histone modification patterns and also DNA methylation.
Several reasons support the choice of this ex-vivo model to study how activation of differentiation signals could result in transformation suppression.
This transition involves enormous remodeling of the cell and is likely driven by genetic aberrations, extracellular signals, and the activation of differentiation programs in the cancer cells.
Thus, we hypothesize that radiation-induced activation of differentiation-related genes, results in premature differentiation of cells in the embryonic brain.
Modelling of microgravity effects, meanwhile, suggested an inhibition of osteogenic differentiation and activation of adipogenic differentiation of mesenchymal stem cells [ 88, 96, 98– 102, 102– 104].
However, sequential inhibition and activation of molecular differentiation pathways now allow a targeted and efficient differentiation of human pluripotent stem cells into various lineages.
Detailed marker analysis suggested that early activation of cardiac differentiation by Nodal −/− XEN CM caused premature differentiation and subsequent depletion of cardiac progenitors.
Therefore, we hypothesise that MYCN is necessary during the activation of neuroblastoma differentiation to induce apoptosis in cells that are not committed to differentiation but are still proliferating.
