The phrase "activation of damage" is correct and usable in written English.
It can be used in contexts related to the initiation or triggering of damage, often in technical, medical, or scientific discussions.
Example: "The activation of damage in the cells was observed after exposure to the harmful substance."
Alternatives: "triggering of damage" or "initiation of damage".
Furthermore, this changes the role of H2O2 from an inflammatory chemoattractant to an activator signal that primes immune cells to respond to damage cues via the activation of damage receptors such as Draper.
During bending, the developed stresses lead to the activation of damage mechanisms like matrix cracking, fiber pull-out delamination and in succession or in overlap.
Moreover, activation of damage response pathway of the DNA leads to cell cycle arrest at G2/M phase, accumulation of cells in pre-G1 phase and annexin-V and propidium iodide staining, indicating that cell death proceeds through an apoptotic mechanism.
After this phase, the activation of damage mechanisms of the joint occurs.
Therefore, molecular damage and autonomous activation of damage-sensing signal-transduction pathways may contribute to hyperfunction, not vice versa.
Another mechanism for p53-induced autophagy is through transcriptional activation of damage-regulated autophagy modulator (DRAM), a p53 transcriptional target [58].
Thus, the pathological effects of TNF observed in the retina can be explained in part by the activation of damaging signaling cascades in RGCs directly and indirectly due to the TNF-mediated neurotoxic activity of astrocytes.
DNA damage leads to activation of DNA damage response and repair pathways.
These findings suggest that constitutive low-level DNA damage or chronic activation of DNA damage signalling can cause innate immune activation.
Bartkova, J. et al. Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas.
Thirdly, persistent activation of DNA damage checkpoints and increased numbers of DNA damage foci are present in HGPS-patient derived fibroblasts [ 16, 24, 25].
