Sentence examples for activation of a major from inspiring English sources

Next, we determined the levels of activation of a major intracellular signaling intermediate in the insulin signaling cascade, namely phosphatidylinositol-3 kinase (PI3K).

Given the tremendous physiological and clinical importance of the Kp/GPR54 signaling system, we explored the contributions of the GPR54-coupled Gq/11 and β-arrestin pathways on the activation of a major downstream signaling molecule, ERK, using Gq/11 and β-arrestin knockout mouse embryonic fibroblasts.

These data in sum confirmed that (1) L1-mediated retrotransposition in MCC specifically repressed MCC and not APC and (2) CTNNB1 was strongly induced in all four affected individuals, indicating activation of a major HCC oncogenic pathway.

At a molecular level, cell morphological changes or cytoskeletal responses to GPCRs are thought to be an indirect outcome of signaling cascades, and as a consequence, direct binding and activation of a major cytoskeletal protein by GPCRs are not considered a mechanism at present.

We examined the activation of p38MAPK, a major target of ROS, in cancer tissues to assess the role of CD44v9 in the regulation of intracellular oxidative stress.

To evaluate the upstream kinase affected by As in blunted AMPK activation, we examined the effect of As on the activation of LKB1, a major AMPK-kinase, in N2a cells.

Furthermore, at the molecular level, we looked at the activation of STAT3, a major actor of the mammary gland involution [20].

We first evaluated the activation of mTORC1, a major negative regulator of autophagy [ 31] through the phosphorylation status of one of its downstream target substrates [ 32], the ribosomal protein subunit S6 (S6).

To test whether activation of NFκB, a major transcription factor downstream of MyD88, is required for the elimination of Mp by BMM, we treated BMM cultures with an inhibitor of NFκB activation for 1 hour prior to infection with EYFP-Mp.

This study implicates release of pro-inflammatory cytokines after IgE activation of leukocytes a major mechanism for affecting AAAs among other possible pathways.

To understand the mechanisms underlying the up-regulation of HO-1 expression by pantoprazole, we examined its effects on the activation of Nrf2, a major transcription factor that mediates the ARE/EpRE-driven expression of antioxidant enzymes.