Sentence examples for activation of a broad from inspiring English sources

Both the gonadotropins and the EGF-like peptides possess the capacity to stimulate resumption of oocyte meiosis in vitro via activation of a broad signaling network in cumulus cells.

Thus, the concomitant induction of EZH2 and attenuation of Nkx3.1 can explain the activation of a broad dedifferentiation program observed in the transcriptome of ERGhigh and ESE3low tumors.

Those increased levels suggest the activation of a broad range of immune cells during CM as well as their alteration, secondary to the cerebral processes [22], [23].

Recent molecular studies indicate activation of a broad range of defense responses during induced resistance.

Ras-GTPases are potential candidates that can transduce the constitutive and concurrent activation of a broad array of effectors such as ERK and AKT.

The NF-κB family of transcription factors [p65, p50, p52, RelB, and c-Rel] is involved in the activation of a broad range of genes involved in inflammation, differentiation, tumourigenesis, metastasis, embryonic development, and apoptosis [ 11, 12, 14].

Although Scf elicited rapid responses in some intracellular pathways that we interrogated (Ras/MAPK, PI3K/AKT) in all of the HSC/HPC cellular subsets we analyzed, Thpo stimulation profiles were stronger in HSC/MPP (compared to GMP/CMP or MEP) and consisted of the activation of a broader array of intracellular pathways (Ras/MAPK, PI3K/AKT, JAK/STAT).

In particular, TLT CD4+ T cell activation i) is quantitatively increased, ii) is characterized by the activation of a broader range of T cell clones, iii) is stochastic, i.e. characterized by the absence of shared pattern of TCR perturbation in genetically identical couples of donors and recipients.

Because FOXA1 is expressed only weakly in the transformed cells, transduction with a FOXA1 vector might lead to the activation of a broader range of ERα target genes and suppression of the squamous phenotype.

The second signal required for NLRP3 activation consists of a broad range of infection or stress-associated signals, and due to the diverse nature of these signals, it is unlikely that direct interactions with NLRP3 would induce its activation [ 197].

As such, SC3 asked for a prediction of the activation status of a broad range of gene sets in subset B of human cells (Fig. 1A), provided similar data as in SC2, along with gene set enrichment scores with associated significance values for subsets A and B in rat and subset A in human.