Sentence examples for activation loop from inspiring English sources

It is known that phosphorylation in the activation loop activates various protein kinases.

Most kinase activities are regulated via the activation loop located at the active site.

LKB1 phosphorylates a critical threonine in this activation loop to activate AMPK.

L861Q: L861Q is a frequently occurring activating mutation in the activation loop of EGFR [47].

For one, clustering induces intermolecular autophosphorylation, which stabilizes an active conformation of the activation loop.

Mutation of phosphorylatable residues in the activation loop abolished PKC activity [ 42, 43].

The 431 residue MST3 is activated by autophosphorylation of the activation loop Thr [ 19].

Human Mps1 auto-activates by phosphorylating T676 in its activation loop.

MST2 is activated by dimerization and autophosphorylation of the activation loop.

Lyn can then trans-autophosphorylate within the activation loop (Y397) to generate a highly active enzyme.

GAK was shown to be constitutively active in the absence of phosphorylation of the activation loop.