Exact(9)
Chronic immune activation is regarded as a central triggering factor for inflammatory rheumatic diseases.
Therefore, controlling microglial activation is regarded as a promising therapeutic target to combat neurodegenerative diseases.
IgE-dependent mast cell activation is regarded as the basis of clinical symptoms of food allergy [ 5].
Telomerase activation is regarded as a central step in carcinogenesis and, here, we demonstrate telomerase activation in premalignant skin lesions and also in all forms of skin cancer.
A deficiency in the mechanism of oocyte activation is regarded as the principal cause of fertilisation failure, or abnormally low fertilisation after ICSI, and can recur in successive ART cycles [ 3, 123, 136].
Deficiency in the mechanism of oocyte activation is regarded as the principal cause of fertilisation failure following ICSI, accounting for an estimated 40% of failed cases [ 3, 123- 125].
Similar(51)
Traditionally microglia activation was regarded as a stereotypic and graded process with devastating consequences for the surrounding neurons.
The initial variance at the holding potential of −90 mV before activation was regarded as background variance and subtracted from the recordings.
The tumor suppressor CYLD encodes for a deubiquitinase that plays a critical role in the regulation of NF-κB and activation of caspase-8, its activation being regarded as a therapeutic target in the treatment of cancers [ 48].
Genome-wide gene activation in the zygote, termed zygotic gene activation (ZGA), is regarded as crucial for embryos to acquire the potency to form all cell types.
As IL-2 is also involved in T-cell activation and is regarded as a 'T-cell growth factor', IL-2Rα (CD25 -blocking agents CD25 -blockinge.
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