The phrase "activation is necessary for" is correct and usable in written English.
It can be used when discussing the requirement of activation for a process, function, or system to work properly.
Example: "In order for the software to function correctly, activation is necessary for the license key."
Alternatives: "activation is required for" or "activation is essential for".
MAPK plays a major role in diverse cellular and neuronal activities, and its activation is necessary for consolidation of long-term memory and LTP (for review see [32]).
A second possibility is that activation of spatially segregated RyR1 and RyR2 channels creates Ca2+ microdomains within the soma and the dendritic processes and terminals (Berridge 2006) whose coincident activation is necessary for enhancing activity-dependent dendritic growth.
Moreover, chemokines activate resident microglial cells and such activation is necessary for dendritic remodeling to occur [ 18].
In this study, we did not examine the effect of cyclophosphamide, although this drug is included in a popular CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisone or prednisolone) regimen with prednisolone, vincristine, and hydroxydaunorubicin, because in vivo activation is necessary for cyclophosphamide to become active 16.
In monolayer culture, autocrine EGFR activation is necessary to activate AKT [ 30], so we determined whether autocrine EGFR activation is necessary for AKT activation in organotypic culture.
Recently, we and others have demonstrated that β-adrenergic receptor (β-AR) activation is necessary for retrieval using both rat and human memory models.
Given that CXCR4 is a GPCR and its activation is necessary for identifying its role, we evaluated the expression of CXCR4 and its ligand CXCL12 in various cell lines, viz.
These data suggest that a reagent that can block both the direct and indirect activation is necessary for a discordant xenotransplant.
In agreement, other groups showed that antisense mRNA for TRPA1 prevents carrageenan-induced inflammatory hyperalgesia, suggesting that channel activation is necessary for both the development and the maintenance of hyperalgesia [45].
PLCγ1 activation is necessary for FGF-2-induced capillary tube formation in vitro.
p38 activation is necessary for muscle development which leads to phosphorylation of substrates involved in the myogenic process.
