Taken together, this clearly demonstrates that C3G functions as an activator of Rap1 and that this activation is involved in the regulation of cell adhesion.
These results confirm that STAT3 activation is involved in IL-9 induced CCL11 promoter activity.
To determine whether caspase activation is involved in Cre-induced cardiomyocyte apoptosis, we determined the activity of caspase 3.
It is thus likely that inhibition of macrophage activation is involved in the mechanism of these anti-inflammatory and antitumor activities of DHMEQ in mice.
Importantly, hypothalamic activation is involved in migraine pathophysiology.
Cardiac mast cell activation is involved in the process of myocardial ischemia reperfusion (I/R) injury and exacerbates myocardial infarction.
Meningeal nociceptors represent the first-order neurons of the trigemino-vascular system, whose activation is involved in the initiation of migraine headache [137].
There are reports suggesting that peroxynitrite-induced PARP activation is involved in renal hypoperfusion and in impaired endothelium-dependent vasodilation [23].
Together our data suggest that 5-HT2A receptors activation is involved in the regulation of distribution of cytoskeleton in the dendritic spines.
Antigen specific activation is involved in the formation of CD45RO+ T cells [15].
Because Rho/ROCK activation is involved in CXCR4 signaling, we examined its' possible activation by the SDF-1α ligand.
