The phrase "activation disease" is not a standard or widely recognized term in written English.
It may be used in specific contexts related to medical or scientific discussions, but clarity is essential to ensure the intended meaning is conveyed.
Example: "Researchers are investigating the role of activation disease in autoimmune disorders."
Alternatives: "triggering illness" or "stimulus-related condition".
At enrollment we recorded sepsis signs, plasminogen activator inhibitor 1 (PAI-1, an inhibitor of fibrinolysis) activity and concentration, prothrombin fragments 1 + 2 (F1+2) concentration (a marker of coagulation activation), disease severity and organ dysfunctions.
It is possible, however, that IL-1R1 could be a Treg-specific marker in chronic activation disease conditions such as HIV infection, in which higher levels of CD25+ cells that are not suppressive are present, possibly due to chronic immune activation [16], [44].
This technique may also enable the identification of genes and expression patterns associated with the type of disease, stage of activation, disease progression and molecular therapeutic mechanisms.
Moreover, in a lupus nephritis model (MRL-lpr mice), in the absence of factor H (which leads to uncontrolled AP activation) disease progression is accelerated [ 10].
With respect to systemic MC activation disease (MCAD) [ 17, 18], the clinical efficacy of the BDZs flunitrazepam, diazepam, bromazepam, and midazolam for the treatment of MC mediator-induced symptoms has been reported [ 18, 19].
Furthermore, the failure of the declining CD4 T cell population to regulate and maintain granulomas is one of the mechanisms proposed to be behind the increasing risk of re-activation disease in latently infected individuals with HIV.
These diseases are recognized as macrophage-activation diseases, because increased proinflammatory cytokines such as IL-6, TNF-α, and IL-18 are dominantly produced by macrophages [ 20, 21, 25, 35, 36].
sMer and sCD163 are valuable biomarkers of M2c activation and disease activity in SLE.
Given the strong association between inflammation/immune activation and disease outcomes in treated HIV disease, defining the mechanisms associated with HIV-associated inflammation is of high importance.
Based on the essential pathogenic role of inflammation for progression of liver diseases, we hypothesized that sIL-2R might be an indicator of inflammatory cell activation and disease severity in patients with chronic liver diseases (CLD).
Detailed analysis to correlate thrombin activation with disease pathology 21 will be required to understand the disease significance of localized thrombin activation within plaques.
