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The selective synthesis of 1,2-cis-hexofuranosyl 1-phosphates was readily accomplished according to a procedure based on the 'Remote Activation Concept'.
Together, these experiments demonstrate the possibility of adapting the target-dependent activation concept to various types of nucleic acid enzymes.
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The paper describes decisive factors in prodrug designing, such as enzymes participating in their activation, concepts of chemical modifications in the group of antiviral drugs and new anticancer treatments based on prodrugs (ADEPT, GDEPT, LEAPT).
The chemical responses of both asphalts were measured, and the flow activation energy concept was used to understand the resulting changes in the physical and rheological properties after immersion in distilled water for one year.
Results indicate that the activation energy concept of ASR can be seen as a useful parameter and has the potential of playing the role of a screening parameter for rocks with different reactivity.
Again, very suggestively but of potential importance for a novel activation mechanism concept, the observed predicted cavity enters into an opening the A-domain of HbpR (Fig. 1C).
If progress in theoretical neuroscience continues, it should become possible to tie psychological to neurological explanations by showing how mental representations such as concepts are constituted by activities in neural populations, and how computational procedures such as spreading activation among concepts are carried out by neural processes.
This increased activation of concepts and ideas is similar to Guilford's (1967) conception of divergent thinking and also is one of the key processes Mednick (1962) suggested to be involved in creative thinking.
Lupyan, G. & Thompson-Schill, S. L. The evocative power of words: activation of concepts by verbal and nonverbal means.
The activation of concepts is automatic – meaning when it happens, we aren't aware of it.
From a cognitive science perspective, salience involves selective activation of concepts related to the target reinforcer in memory (Bower, 1981; Volkow et al, 2002).
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