The phrase "activation checkpoint" is correct and usable in written English.
It can be used in contexts related to biology, immunology, or computer science, referring to a point at which a process is regulated or controlled.
Example: "The activation checkpoint plays a crucial role in regulating the immune response to ensure that T cells are activated only when necessary."
Alternatives: "activation control point" or "regulatory checkpoint".
1) A key conclusion in the manuscript, stated in the title, is that SETD2 is involved in the 'p53 activation checkpoint'.
Our analysis of the molecular circuitry underlying this replication origin activation checkpoint reveals that G1 arrest is dependent on three nonredundant checkpoint axes coordinated through the Forkhead transcription factor FoxO3a and p53.
Therefore, the major concerns that will have to be addressed for this manuscript to be considered for publication are: 1) A key conclusion in the manuscript, stated in the title, is that SETD2 is involved in the 'p53 activation checkpoint'.
In contrast, Her2 and triple negative tumours show a marked response to Cdc7 inhibitors with potent cancer-cell-specific killing as a result of overexpression of the target protein and a result of impairment of the origin activation checkpoint due to p53 lesions.
Various B cell-targeting strategies could be used for the treatment of autoimmune rheumatic diseases, such as B cell depletion, blockade of activation checkpoints, inhibition of pro-inflammatory cytokines, triggering of B cell inhibitory checkpoints and trafficking blockade.
These mechanisms include the activation checkpoints and induction of cell cycle arrest, to allow the cell time to repair the damage.
Together our findings indicate that PP5 plays an essential role in the activation and checkpoint signaling functions of ATM in cells that have suffered DNA double-strand breaks.
We investigated activation of checkpoint signaling and induction of cell cycle arrest following exposure of iPS cells to γ-radiation.
Activation of checkpoint responses to genotoxic stress is one of the main barriers to prevent carcinogenesis (reviewed in [36]).
In humans, Timeless-Tipin interacts with Chk1 and ATR to control activation of checkpoint kinase Chk1 [32], [33], [34], [34].
Under these conditions, activation of checkpoint pathways initially induces cell cycle arrest, allowing time for DNA repair to occur.
