Sentence examples for activation blocking from inspiring English sources

Furthermore, Atiprimod inhibited signal transducer and activator of transcription (STAT) 3 activation, blocking the signalling pathway of interleukin-6, which contributes to myeloma cell proliferation and survival, and downregulated the antiapoptotic proteins Bcl-2, Bcl-XL, and Mcl-1.

Several mechanisms blocking the activation of apoptotic pathways, including caspase 9 activation blocking, have been postulated in GBM cells, which could explain the low level of this protein in GBM [36,37].

A first generation of CyP inhibitors (e.g. Debio-025 or NIM811) has overcome the problems connected to the immunosuppressant activity of CsA, caused by the formation of a CyP-A/CsA complex in the cytosol that inhibits lymphocyte activation, blocking the NF-AT transcription factor [36].

Regarding therapies that target autoreactive lymphocyte activation, blocking T-cell help with CTLA4Ig, an immunosuppressive agent, was successful in mice (Finck et al., 1994), and this approach is now FDA approved for rheumatoid arthritis (Bluestone et al., 2006).

While adding recombinant CSF-1 reduced macrophage expression of MHC II following LPS activation, blocking it with a soluble recombinant CSF-1R allowed a marked activation of these cells.

Moreover, irradiation-induced lung fibrosis in mice associates with a significant increase in PDGFR activation; blocking PDGFR signaling by specific tyrosine kinase inhibitors attenuates fibrosis and increases survival in these mice [ 20].

Furthermore, the inhibition of APJ expression, PI3-K/Akt activation, or ERK activation, blocked effects of apelin on decreasing the activity of ALP.

The inhibition of SP-1 activation blocked the SDF-1-induced expression and activity of the u-PA promoter [ 44].

Meanwhile, fludarabine, an inhibitor of STAT1 activation, blocked IFN-γ-mediated IDO expression.

Sensitization of ACHN cells to TRAIL-induced apoptosis required caspase activation (blocked by ZVAD-FMK, a caspase inhibitor – Figure 3c).

Furthermore, COX-2 expression has been correlated with ERK1/2 activation, whereby inhibition of ERK1/2 activation blocked the producton of COX-2 production [ 25, 26].