Studying T cell activation in array format could be quite useful in identifying the roles of various T cell or antigen-presenting cell membrane proteins in this process.
All results discussed here are based on our Macrophage Activation State array (human and mouse) focusing on genes involved in the immunobiology of cells of macrophage lineage.
The rationale for developing rapalogs for treatment of triple-negative breast cancer (TNBC) is based on the recent detection of a high frequency of PTEN loss, which is known to correlate with AKT activation, in array comparative genomic hybridization studies [ 24, 25].
We investigated the possibility of a tyrosine kinase with differential activities in UM and UM metastasis to be responsible for ERK1/2 activation, using an array of kinase activity assays.
Transcription factor DNA-binding activities were measured using Transcription Factor Activation Profiling Plate Array II (Signosis, Sunnyvale, CA, USA) in nuclear extracts prepared from RANKL overexpressing cells using NE-PER nucleandand cytoplasmic extraction reagents (Thermo Scientific, Rockford, IL, USA).
It has been demonstrated that intracellular TGF-β1 signaling occurs by the activation of an array of signaling routes.
Among the targets, damage to DNA integrity is critical and elicits a global stress response that is characterized by activation of an array of signaling pathways.
Upon growth-factor stimuli, activation of an array of the intracellular signalling pathways induces conformational change in the integrin cytoplasmic domain that transmits to the extracellular domain.
Perception of LPS leads to the activation of an array of defense genes in A. thaliana in support of innate immunity and MTI [ 32, 33].
Thus, ROS and calcium may act as early second messengers in the transcriptional activation of an array of defense-related genes in rice roots under FA stress.
Overall, our results suggest that several core HSC behavioral programs can be functionally uncoupled, allowing their differential and combinatorial activation by an array of external factors.
