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Studies were consolidated qualitatively into four outcome categories: activation, anxiety, and mood; relaxation/sleep; personal comfort ratings; and depression.
Four studies examined the effects of negative and positive air ions on activation, anxiety, and mood [ 15, 16, 25, 27].
Fifteen studies on activation, anxiety, and mood examined the effects of negative air ions only [ 5, 9, 10, 12, 14, 18, 26, 28- 35].
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In the current study, we found a correlation between preoperative bilateral amygdala activation and anxiety and depression levels preoperatively in right TLE patients, characterized by greater anxiety and depression scores with greater fMRI activation.
The positive correlation between insula activation and anxiety level suggests that the posterior part of the insula also may be involved in the neurobiology of anxiety.
MK-8825 did not exert any effect on CSD induced amygdala activation and anxiety behavior.
This choice was based on previous observations showing no metabolic, immune-endocrine and behavioral evidence of stress activation or anxiety in group-housed siblings (see [33], [34], [80] for details).
The second notable finding of this investigation concerns modulation of activation by anxiety level during emotional information processing.
In contrast, left TLE patients did not show a correlation between amygdala activation and anxiety and depression scores.
The correlation of amygdala activation with anxiety and depression in those with right TLE suggests a modulatory role for the right amygdala on mood.
The important implication is that divergent findings reported in the imaging literature on depression could reflect modulation of activation by anxiety level in response to different emotional information.
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