Sentence examples for activation and suppressing from inspiring English sources

Roose and colleagues report that the RasGRP1 and SOS1 guanine nucleotide exchange factors have opposing roles downstream of the EGFR, with RasGRP1 restricting SOS1-induced KRAS-ERK activation and suppressing intestinal tumorigenesis.

Therefore, therapeutic strategies may be theoretically achieved by both diminishing B-cell activation and suppressing FcR-mediated immune responses.

These results suggests that HMG-CoA reductase inhibitors induce lymphoma cells apoptosis by increasing intracellular ROS generation and p38 activation and suppressing activation of Akt and Erk pathways, through inhibition of metabolic products of the HMG-CoA reductase reaction including mevalonate, FPP and GGPP.

In conclusion, the present study demonstrates that treatment with HMG-CoA reductase inhibitors induced apoptotic death in ML cells, by increasing intracellular ROS generation and p38 activation and suppressing activation of Akt and Erk pathways, through inhibition of metabolic products of the HMG-CoA reductase reaction including mevalonate, FPP and GGPP.

We demonstrated that statin induces lymphoma cells apoptosis by increasing intracellular ROS generation and p38 activation and suppressing activation of Akt and Erk pathways, through inhibition of metabolic products of the HMG-CoA reductase reaction including mevalonate, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP).

However, fluvastatin showed more cytotoxicity towards lymphoma cells than other two statins, by increasing intracellular ROS generation and p38 activation and suppressing activation of Akt and Erk pathways, through inhibition of metabolic products of the HMG-CoA reductase reaction including mevalonateFPP and GGPP.

have shown in oral squamous carcinoma that VEGF triggers endothelial cells to secrete prostaglandin E2 (PGE2) which is an immune suppressant and disrupts T cell activation and suppresses T cell proliferation and cytotoxic functions 54.

Glycyrrhetinic acid also reduced TNF- α production and NF- κB activation and suppressed mouse ear inflammation stimulated by tissue plasminogen activator.

Moreover, SFN inhibited GalN/LPS-induced caspase-3 activation and suppressed FAS and FASL expression.

At a concentration of 5 µM, GSI inhibited ligand-dependent activation, and suppressed expression below the basal level observed in co-culture with the parental 3T3 Flp-in cells, as might be expected based on the ability of GSIs to block the activity of all Notch family members expressed on the tumor cells (Figure 4).

High salt also potentiated lipopolysaccharide-induced macrophage activation and suppressed interleukin 4-induced macrophage activation.