Sentence examples for activation and repressive from inspiring English sources

The following studies have found evidence of a global increase in DNA methylation following a period of hypoxia with associated changes in transcriptional activation and repressive histone marks.

Presence of H3K14ac on inactive promoters along with H3K9me3 and H3K27me3 is in agreement with previous observation where high throughput characterization of combinatorial histone marks using proteomic approach shows highest abundance for H3K14ac peptide with activation and repressive marks [ 51].

Our nucleosome-ChIP studies did not show any enrichment of H2A or H4 S1ph with known activation and repressive histone PTMs in either later staged embryos or somatic human cells.

To determine whether the expression of miRNAs in the mammary gland was subject to epigenetic regulation, we utilized ChIP-seq data for H3K4me3 and H3K27me3 (activation and repressive marks, respectively) to investigate histone methylation of the regulatory regions of miRNAs spanning a region 3 kb upstream of their putative transcriptional start-site (TSS).

A similar cyclical process that entails alternating activating and repressive epigenetic events during the hormone-dependent activation of genes has been described [ 56].

SUMMARY: The chromatin remodeling factor Brg1 is essential for mesoderm induction and, by modulating active and repressive chromatin states, is involved in promoting the activation of dynamic enhancers.

Thus, Brg1 is essential for modulating active and repressive chromatin states during mesoderm lineage commitment, in particular the activation of developmentally important enhancers.

Chromatin barriers function to demarcate active and repressive chromatin domains.

Are active and repressive domains spatially partitioned?

To better understand the function of the HSI2 PHD-like domain, interactions between activation-associated and repressive histone methylation marks at the Kan R and Kan S transgene loci were evaluated by ChIP-qPCR assays.

Furthermore, for the first instance, we identified H3K36me2 as a global repressive mark in P. falciparum and revealed a unique mode of regulation of gene expression by altering the ratio of activation and repression marks.