Sentence examples for activation and execution from inspiring English sources

These clusters, along with those that represent biochemical control mechanisms for signaling and gene expression at the protein level, such as kinases (90 clusters) and phosphate-transfer activities (154 clusters), may represent critical elements in the activation and execution of the cellular recovery processes necessary for the mechanism of desiccation tolerance exhibited by Tortula ruralis.

The mitochondrial response includes the release of cytochrome c into the cytosol where it binds to Apaf-1, allowing the recruitment of caspase-9 and the formation of an apoptosome complex, resulting in caspase-3 activation and execution of cell death (Green and Reed 1998).

This observation rules out the possibility that genetic redundancy masks a role of DNase II genes in cell death activation or in regulating the kinetics of apoptosis and is consistent with the model that DNase II genes act at a later stage of apoptosis after cell death activation and execution have occurred [3].

In general, the caspases are crucial for the activation and execution of apoptosis.

Apoptosis is a complicated process and its proper execution programme requires the coordinated activation and execution of several pathways.

In studies of the DNA damage response, most attention has been focused on the activation and execution of that response.

CED-4 translocation induced by the cell-death activator EGL-1 was blocked by a gain-of-function mutation in ced-9 but was not dependent onced-3 function, suggesting that CED-4 translocation precedes caspase activation and the execution phase of programmed cell death.

However, there are still unbridged gaps between RARβ activation and apoptosis execution.

We now examine the requirement for the PIDDosome in caspase 2 activation and the execution of caspase-2-mediated neuronal death, specifically death induced by Aβ or by NGF deprivation.

Mitochondrial release of apoptogenic molecules, particularly cytochrome c (cc) and the subsequent formation of the apoptosome complex which in turn leads to caspase activation and ultimately apoptosis execution is a key event in downstream apoptosis signaling.

Caspase-9, a mitochondria-mediated initiation caspase, is directly activated by Apaf-1 and cytochrome c and triggers activation of execution caspases 3, 6, and 7, leading to DNA fragmentation and cell death (Li et al, 1997).