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CD46, a regulator of complement activity, promotes T cell activation and differentiation towards a regulatory Tr1 phenotype.
The expansion of ASC in SLE patients with active disease probably reflects increased activation and differentiation.
Two rhein derivatives d6 and d11 inhibited BMMs activation and differentiation with 98% and 85% inhibitory activity respectively, without showing any cytotoxicity on BMMs.
Therefore, the differential glycosylation state of cell-surface glycoproteins during immune cell activation and differentiation can selectively regulate cellular signaling.
Approaches of targeting excessive activation and differentiation of osteoclasts were considered as an effective treatment option for osteoporosis or osteopenia.
Evidence of efficient macrophage activation and differentiation were detectable within organized structures in the spinal tissue, irrespective of HIV status.
An altered expression of myogenic regulatory factors involved in satellite cell activation and differentiation, however, might reflect perturbations of muscle repair in s-IBM.
Muscle repair relies on coordinated activation and differentiation of satellite cells, a process that is unable to counterbalance progressive degeneration in sporadic inclusion body myositis (s-IBM).
Here, we examined the VSSP adjuvant effect on the humoral and cellular responses, dendritic cell (DC) activation, and differentiation of Th cells.
Its activation promotes T cell activation and differentiation.
Detection of autoantibody indicates the activation and differentiation of gastric antigen-specific B cell clones.
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