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CD40L, is a costimulatory molecule that is expressed on activated CD4+ T cells and is involved in their activation and development of effector functions [ 23].
Because TGF-β1 treatment also increased GSK3β expression and activity, GSK3β could play an essential role in TGF-β1-signaling-mediated fibroblast activation and development of fibrosis.
The link between C5a receptor activation and development of apoptosis and gliosis is well known.
Mutations of KIT receptor tyrosine kinase are involved in the constitutive activation and development of human hematologic malignancies.
Results in this paper describe the robust and sustainable functionalized polymeric platform that can be used effectively for protein activation and development of novel biosensors.
The Stat3 SH2 domain is essential for its activation, and development of a potent SH2 inhibitor will be therapeutically valuable in treating cancers with constant Stat3 activation.
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This article describes the processes occurring and factors controlling primordial follicle formation, activation, growth, and development to the ovulatory stage.
This chapter describes the processes occurring and factors controlling primordial follicle formation, activation, growth, and development to the ovulatory stage.
However, studies have also identified a large number of diverse biological functions for Syk, including cellular adhesion, phagocytosis, osteoclast maturation, platelet activation, and vascular development.
Actually, defects in the development of PGCs, meiosis, follicle formation, follicular activation and follicular development could all cause POI.
In a mouse model of spontaneous mammary carcinoma, the depletion of Tregs resulted in CD4+ T-cell activation and subsequent development of efficient CD8+ T-cell activity [ 41].
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