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Unlike the two Spx activation mutants, the SpxG52R mutant protein was completely impaired in activating transcription from the mutant promoter.
Our results supported the notion that mitochondrial ROS actively participate in microglia-mediated pathogenesis by altering MAPK kinase cascades and activating transcription factors NF-κB in microglia cells.
Activating transcription factor.
activating transcription factor 4. autophagy-related genes.
activating transcription factor 6. cystic fibrosis.
ComA binds to recognition elements (RE) in bacterial promoters, activating transcription.
activating transcription factor 3/4/6. immunoglobulin heavy chain-binding protein.
Activating transcription factor 6 (ATF6) is an ER resident transcription factor and a key component of the UPR [5].
NF-κB is a cytosolic transcription factor binding to nuclear DNA and activating transcription of target genes.
In parallel, these TRAFs are important in activating transcription factors NF-kB and/or IRF-3 by hMPV.
Moreover, both CgIκB1 and CgIκB2 are able to inhibit NF-κb/Rel activating transcription in S2 or HEK293 cells.
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