Sentence examples for activating role of from inspiring English sources

In the case of Gata2, its reduction mainly caused downregulation of mast cell-specific genes, consistent with the known activating role of GATA2 (Masuda et al, 2007).

The results from the HT29-APC cell line where Apc was activated or β-catenin silenced, imply an activating role of the Wnt pathway on Notch-2 and the downstream target gene Hes-1 [31].

The apparent activating role of Fyn on PPARγ activity through a negative regulation of Erk1/2 is rather intriguing and suggests that other components may modulate Src/Fyn response to ghrelin.

Figure 3(a) shows an example in which removal of node A leads to the disruption of C, D, G, H, and I, but does not eliminate nodes B, E, F and J, since there are two independent signaling interactions activating B. Removing an original node simulates the knockout of a signaling component and evaluates the importance of the activating role of this component.

The overall supralinearity is in line with an activating role of complexin in exocytosis by a reduction of the activation energy for fusion.

Therefore, we asked whether the putative activating role of 14-3-3 14-3-3 14-3-3tituted by the short couldxy-terminal sequence of a 14-3-3 independent bet otherwisubstitutedus toxin.

Much therefore remains to be learned regarding the activating roles of posttranslational modifications in HSF1 regulation, their role in stress mediated transcription and the mechanisms by which such modifications are recognized by regulatory pathways in cells and converted into altered function.

As expected by the transcription activating roles of CBP, RA and DNA demethylation, all three conditions resulted in gene activation in the majority of cases.

Finally, the Wnt-activating role of USP7 is specific to APC mutations; thus, it can be used as a tumor-specific therapeutic target for most CRCs.

The most significant line of evidence which contradicts the previously proposed carcinogen-activating role of CYP1A1, comes from Nebert and the generation of Cyp1a1 knockout mice.

In this review, a comprehensive summary of the carcinogen-activating role of CYP1A1 is presented, in terms of substrate specificity, mechanisms of carcinogen activation, polymorphisms and extrahepatic expression.