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Reactive oxygen species (ROS) act as intracellular messengers activating multiple signalling pathways, including activation of c-Jun N-terminal kinase, extracellular signal regulated kinases, NF-κB and activator protein-1 [ 34].
Given the similarity of actions between PPAR and RXR activation, RXR activation may be exerting its effects by concurrently activating multiple PPAR pathways.
In fact, although Myostatin is not a transcription factor, it transmits the signal of TGF-beta cytokines activating multiple intracellular pathways resulting in phosphorylation and activation of downstream Smad proteins and other signalling molecules (e.g. Akt, MAPK, mTOR and Src).
Constitutive activation of STAT3 provides cancer cells with growth and survival advantages through activating multiple signaling pathways and regulations of a broad range of gene expressions in the cells.
In [3], Navarro-Serment et al. present their work that is related to the inspection of moving targets in RoI by activating multiple cameras which distributes the collective tasks of identification and prevent energy consumption on a single robot.
Findings show that various forms of arts and design (including poetry, photography, art installations, motion graphics videos, data visualization) play an important role in connecting metaLAB to external stakeholders and in activating multiple value drivers.
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Therefore AKT activation is neuroprotective in the STS injury model — indicating that AQ2S is activating multiple-survival mechanisms.
A single activated receptor may then activate multiple downstream molecules, resulting in the signal amplification of a zymogen cascade.
Wnt proteins (secreted, lipid modified glycoproteins) regulate various cellular activities owing to their potential to activate multiple signal transduction pathways.
Phosphorylated AKT activates multiple downstream pathways, including FOXO3 phosphorylation, resulting in oocyte activation [ 8].
If you activate multiple sensors too early, the Hub has trouble pairing with them.
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