Sentence examples for activating mark from inspiring English sources

In our analysis (Figure 4), we found that RAS up-regulation activated the expression of ERK by multiplex phosphorylation, which finally regulate the mitosis by activating MARK.

Acetylation of histones increases accessibility of chromatin, which results in higher gene expression and is therefore seen as activating mark 16– 16.

However, the dual presence of a silencing and activating mark on the same peptide led to vastly distinct turnover rates compared with either mark alone.

Additionally, loss of Lsh leads to the accumulation of the "activating" mark H3K4me2 globally [ 29], while the repressive mark H3K9me3 is reduced [ 26].

While the H3K4me3 (activating) mark is increased in both activation states (more so during TLR4 engagement), the appearance of the H3K27me3 (repressive) mark is reduced on BCR-responsive genes but remains relatively unchanged in LPS-responsive genes [ 3].

SMYD3 is an HMTase specific for both di- and trimethylation of H3K4, catalyzing H3K4me2/me3, a transcriptional activating mark [6].

However, during the heterochromatin euchromatin switch silencing marks are replaced by activating marks, and this leads to the activation of genes in a specified genomic region (Brown 1966; Grewal and Jia 2007; Heitz 1928; Huisinga et al. 2006).

Are different activators responsible for recruitment of putative H3K9me3 lysine demethylases (KDMs) to reverse heterochromatic marks and for attracting HATs to place activating marks?

Consequently, transcriptional activation of SM clusters requires reprogramming of the chromatin landscape and replacement of repressive histone marks by activating marks.

The latter is mediated by specific interactions between the modified histone tails and the corresponding enzymes and leads to self-perpetuation of activating marks on chromatin.

Thus, with the exception of Hoxb1, an increase in activating marks even in the absence of Polycomb-associated silencing, does not, in itself, induce transcription.