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Hence, MMP activities have been implicated in EMT by activating growth factors and their receptors and cleaving cell-cell and cell-ECM adhesion molecules.
MMP activities have been implicated in EMT by activating growth factors and their receptors and cleaving cell-cell and cell-ECM adhesion molecules.
Taken together, this suggests that FOXO-induced CTDSP2 plays a role in activating growth factor signalling, in particular the activity of the Ras Raf MEK ERK pathway.
The APP-SSF had a greatly positive effect on FAE production by A. niger, by enhancing mass and heat transfer and activating growth and metabolism.
Recently, Chen et al. [ 40] demonstrate a cooperation between FoxO and deltaEF1 in activating growth suppressive genes in B lymphocytes.
AKR1C3, therefore, can be positioned as a critical regulatory molecule in activating/inactivating steroid hormone receptors and activating growth factor signaling pathways.
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Administration of replication-competent retroviruses to susceptible mouse strains leads to tumor development, as a result of multiple insertion events and the outgrowth of clones containing one or more proviruses activating growth-controlling genes [15].
Induction of MYC promotes cell proliferation and transformation by activating growth-promoting genes, including the ornithine decarboxylase (ODC1) and CDC25A gene (Nair and Burley 2003).
In cells, Neat1 was shown to be essential for nuclear paraspeckle assembly and maintenance (Clemson et al., 2009; Sasaki and Hirose, 2009; Sunwoo et al., 2009; Mao et al., 2011a, 2011b; Zhang et al., 2012) and Malat1/ Neat2 binds to the Polycomb 2 (proteinotein which is required for activating growth-control genes (Vance and Ponting, 2014).
For example, oestrogen can activate membrane-bound ER and, via G-protein activation, can then activate growth factor receptors such as the epidermal growth factor (EGF) receptor and human epidermal growth factor receptor 2 (HER2/neu) (Filardo, 2002; Johnston et al, 2003).
Interesting in this context is that FOXO activation has been shown previously to activate growth factor signalling (reviewed in [ 38]).
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