Sentence examples for activating feedback from inspiring English sources

These stress responses mobilize the body's resources to respond to a challenge while also activating feedback loops in the brain that help reinstate homeostasis.

Regarding secondary resistance, it has been found that activating feedback loops involving insulin growth factor 1-receptor (IGF-1R)/PI3K can occur during mTOR inhibition, resulting in AKT and mitogen-activated protein kinase activation [ 41, 42].

Such substrates can then ultimately be funnelled into catabolic processes for energy generation whereas, at the same time, activating feedback loops that limit the extent of autophagy; for example, amino acids stimulate the target of rapamycin (TOR), which in turn, negatively regulates autophagy.

One group drove with the system activated (feedback only).

Hyperactive TORC1 can enhance the accumulation of unfolded and aggregated proteins [ 48] and ROS [ 4, 12, 49], leading to stress responses that increase Sestrin expression, thereby activating negative feedback loops that readjust AMPK and TORC1 activity [ 4].

These autoreceptors are located on presynaptic neurons and serve to regulate neurotransmitter release by activating negative feedback loops when neurotransmitter concentrations in the synaptic cleft reach certain levels.

This is modeled by activating the feedback loops Fyn → PAG-Csk and ZAP-70 → cCbl only at a later stage.

The model also simulated the therapeutic administration of anti-CD8 antibodies; this intervention was assumed to activate T-cell production by activating a feedback mechanism blocked by the high numbers of CD8 + lymphocytes present in HIV-infected persons.

Conversely, induction of NF-κB itself results in the generation of ROS via the expression of inducible nitric oxide synthase (iNOS), thus activating a feedback loop that amplifies the process of damage and deterioration in target cells and organs [ 37].

MiR-34a is known to target the class-III histone deacetylase silent information regulator 1 (SIRT1) (Yamakuchi et al. 2008), and expression of miR-34a which miR-34a whichced SIRT1 leadss—contoibutes to a positive p53-activating feedback loop leading to increducedp21 levelSIRT1ereby triggering senescence (Yamakuchi and levels contributes

These results support our model that the enhanced Fyn activity observed upon PAG suppression can activate alternative feedback mechanisms mediated by CTLA-4 and further supports the role of Fyn as a negative regulatory kinase in T-cell signaling [ 27].