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We then combined this stabilizing modification with ring contraction, an activating feature previously unexplored in the context of Cu-free click chemistry, and identified a known thiacycloheptyne that is stable under ambient conditions but reacts with model azides faster than any reported cyclooctyne.
In support of this, we observed that the potential truncated PTB isoform, encoded by the AS-NMD targeted mRNA in which exon 11 is skipped [ 58], is not detectably expressed from cDNA expression vectors (in which there is no NMD activating feature) unless proteasome activity is inhibited by the proteasomal inhibitor MG132 (NJM and CWJS, unpublished observation).
Figure 16 ACTIVATING feature profiles.
A red highlight denotes an ACTIVATING feature.
The lack of an activating feature.
The RF model also identifies the naphthalene scaffold as an ACTIVATING feature.
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Gestures for activating features such the camera and flashlight are also useful, as are options to change the battery icon in the status bar and to arrange the quick settings tiles.
The deactivation of all activating features. .
These patterns represent potentially activating features of the toxic compounds that may then be used to define new alerts.
A local modelling approach for these strongly activating features would likely produce better predictions for these regions of chemical space although more data will still likely be required.
In order to expedite this process a software tool has been developed that can automatically mine representations of activating features directly from toxicity datasets and present them in an interpretable form.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com