Sentence examples for activating effects from inspiring English sources

mGluR5 deletion has been reported to increase novelty-induced locomotor activity [25] and block the locomotor activating effects of cocaine [7] (although see [25]).

Alcohol-induced motor activating effects are consistently shown in mice but rarely demonstrated in adult, outbred rats using conventional behavioral tests.

The environmental context in which psychostimulant drugs are administered can have a large effect on both their acute psychomotor activating effects and their ability to induce the psychomotor sensitization associated with repeated drug administration.

Therefore, activating effects induced by agonists must break these constraints to enable the shift towards the active state.

Here, we demonstrate that preventing GASP-1-mediated downregulation of D2Rs is associated with delays in the development of sensitization to the locomotor activating effects of cocaine.

Importantly, DA signaling is critical for the actions of ethanol and cocaine in flies: disruption of DA signaling blunts the locomotor activating effects of ethanol, alters cocaine sensitivity, and decreases cocaine sensitization [16] [18].

Because there is accumulating evidence that oxidative stress plays a role in pro-inflammatory and immune-activating effects [20, 21], dendritic cells might be activated more efficiently by nSP30 than by larger silica particles.

Increased extracellular DA concentration also activates postsynaptic DA receptors and thereby enhances the motor-activating effects [ 53], as observed in the behavioral dose-response of MPD (Fig. 1).

These results indicate that modulation of D2/3 receptors can, in turn, alter the locomotor-activating effects of morphine.

Westphal's team is now crafting compounds that have more potent sirt1-activating effects than resveratrol, hoping they might help tackle diabetes and Alzheimer's.

The multivariate setting in the MCSF test appears to be sensitive for detecting motor-activating effects of low doses of alcohol as well as reduced locomotion at doses lower than in other behavioral tasks.