Sentence examples for activating differentiation from inspiring English sources

Therefore, these results demonstrated that activating differentiation signals was sufficient to abolish cell response to oncogenic stimuli, thus lending further experimental basis to the differentiation therapy concept.

We anticipated the effect of FGF-10 on cardiomyocyte differentiation is to activate differentiation of mesodermal lineages.

Previous work [ 32, 33] has shown that immobilised BMP2 more effectively activates differentiation of osteoblasts than soluble BMP2.

Sex determination and early gonadal development depends upon specific embryonic gene programs that activate differentiation of the bipotential primodium.

In addition, they are important actors of muscle repair as they activate differentiation of satellite cells, which in turn inhibit differentiation of FAPs into adipocytes under healthy conditions.

Beside the hypothesis that beta1 upregulation might activate differentiation inducing signals, selective inhibition of tumor-promoting pathways should also taken into consideration.

In the presence of the MYCN gene, RA activated differentiation in SK-N-AS cells, as indicated by the neurite outgrowth, with most of them showing a bipolar shape.

The transcriptional factor C/EBP, which forms heterodimers with C-Jun denoted by CREBP1/CJUN, can activate differentiation-specific genes [ 9].

Therefore, these histone demethylases appear to positively regulate Spt6 localization and transcriptional elongation for effective demethylation of H3K27me3 in order to activate differentiation-induced genes.

PPARγ plays a crucial role in MSC differentiation, both by activating adipogenic differentiation and by suppressing osteoblast differentiation (Akune et al. 2004).

Hh ligand exerts a mitogenic effect on mammary stem cells, thereby activating the differentiation of mammary epithelial progenitor cells via differential TP63 promoter selection.