Sentence examples for activating death from inspiring English sources

MADD encodes mitogen-activated protein kinase activating death domain, which interacted with tumor necrosis factor alpha receptor 1 to activate mitogen-activated protein kinase and propagate the apoptotic signal [22].

Apoptosis induced by c-Myc can be mediated through activation of the ARF-MDM2-p53 pathway, or by activating death receptors, such as CD95/Fas [33].

We hypothesized that knockdown of map-kinase activating death domain containing protein (MADD), a TRAIL-resistance factor, may overcome TRAIL resistance in ovarian cancer cells.

Apoptosis can occur through either extrinsic pathway when cells receive external signals activating death receptors or intrinsic (mitochondrial) pathway when pro-apoptotic factors are released from mitochondria after their permeabilization, p53 activating primarily the intrinsic rather than the extrinsic apoptotic pathway [43].

13 NB-UVB induces apoptosis of epidermal T lymphocytes by damaging DNA and activating death receptors.

For example, hepatocytes under the influence of chemotherapy can become susceptible to TRAIL due to upregulation of activating death receptors [ 6- 8].

In the pre-mitochondrial initiation phase, cells recognize danger signals and respond by activating death-inducing pathways but also pro-survival signals in an attempt to fight cellular stressors.

To investigate whether the manipulation of autophagy using these two RNAi constructs would cause any ectopic apoptosis, we immunostained 10-day-old fly brains for Annexin V and activated Death caspase-1 (Dcp-1), respectively, to detect apoptotic cells.

A third cancer drug, in early tests with partner Genentech, activates death signals that trigger cancer cells to commit suicide.

Caspase 3 is a frequently activated death proteases, and required for some typical hallmarks of apoptosis and is indispensible for apoptotic chromatin condensation and DNA fragmentation in all cell types examined [22].

Among them, caspase-3 is a frequently activated death protease, catalyzing the specific cleavage of many key cellular proteins [ 22].