Sentence examples for activating construct from inspiring English sources

In a similar vein, a study employing in utero electroporation of an activating construct suggested that GSK-3 inhibition was essential for radial-guided cortical neuronal migration downstream of STK11 (LKB1) via a mechanism involving APC (Asada and Sanada, 2010).

However, the −92 bp fragment was the most highly activated construct by TIEG1 at the transcriptional level (Figure 5C) suggesting that repression domains are located between −288 and −92 bps which inhibit optimal activation of the Runx2 promoter by TIEG1.

Finally, the in vivo tumor-suppressive effects of MSCs correlates with their ability to inhibit target cell Akt activity, and KS tumors engineered to express a constitutively activated Akt construct are no longer sensitive to i.v. MSC administration.

Neither GR FL nor GRΔLBD was able to activate the construct lacking the GR responsive region Ch25h-12-pRL Ch25h-12-pRL Ch25h-12-pRLot significandly altered upon HC additson, activityurther support for the existence of a response element for unliganded GR contained washinothe -375 to -225 bp region of Ch25h.

The potential discontinuity points of such a self-map in a discrete subset are the so-called switching points at which a new primary self-map in a class is activated to construct the self-map of interest, each of those self-maps depends also on some given switching rule.

We also observed that exogenous E2F was able to activate this construct 2- and 3-fold, respectively, in HaCaT cells (an immortalized line established from human adult keratinocytes) and IMDF dermal fibroblasts [15] (data not shown), indicating that activation of the EBP1 promoter by E2F is not cell type-specific.

Due to the mutation of the LBD, only the synthetic ligand can bind, thereby circumventing binding of natural ligands that activate the construct.

They demonstrate the complexity of his exploration and learning activity, how he activates and constructs knowledge during action, and his emotional states that alternate between feelings of apprehension, enjoyment, and effort.