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Anti-GBM antibodies bind the glomerular basement membrane, activating compliment and proteases, resulting in the disruption of the filtration barrier and Bowman's capsule and causing proteinuria and crescent formation [ 23, 24].
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It is also likely that there was some added therapeutic benefit from the antibody itself as unlabeled antibodies can mediate inflammatory reactions and activate compliment.
Activating Supporters Through Gamification.
This work compliments previous studies using a FGF19 variant that selectively activates FGFR4 and induces hepatocyte proliferation to suggest the role of FGFR4 for induction of hepatocyte proliferation but not for improvement in glucose metabolism by FGF19 [30], [30].
He activated the alarm.
Cruise control is activated.
This activates certain alarms.
Wanderlust: activated.
Sleepiness: Activated.
I'm activated!
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