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Pro-uPA, though termed an 'inactive' precursor, has been shown to possess some minimal intrinsic plg activating capability [ 53].
Our findings could be reconciliated with this fact by assuming that UCNEs have an intrinsic gene activating capability with loose tissue specificity dependent on interactions with neighboring UCNEs to achieve the higher degree of regulatory precision needed for in vivo function.
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Time course studies of p38 MAPK phosphorylation in NHEK treated with anisomycin (300 ng/ml) or IL-1β (10 ng/ml) were performed to assess their p38 MAPK activating capabilities.
However, anti-NF155 antibodies observed in this study were mainly IgG4, which lacks complement binding and activating capabilities.
Interestingly, we have shown that DC-SCRIPT also acts as a NR co-regulator having both repressing and activating capabilities [ 3].
Such studies suggest a possible diagnostic benefit of ex vivo monitoring the complement-activating capability of circulating alloantibodies.
Thus, both modified chemokines and small derivative molecules maintaining the HIV-inhibitory function, but devoid of receptor-activating capability, have been generated.
The mutant is devoid of pro-MMP-2-activating capability but is highly effective in blocking MT1-MMP-mediated FITC-labelled collagen and gelatin film degradation in HTC75 fibrosarcoma and MCF7 breast cancer models.
These CD36 antibodies exhibited PLT-activating capability mediated though FcγRIIa, and, interestingly, PLTs from healthy human subjects exhibited a considerable degree of heterogeneity in their responsiveness to this plasma.
Thus, P/CAF binding to E2F1 in response to TGF β may in fact have multiple functional consequences, affecting not only E2F1 stability but its transcriptional-activating capability as well.
For example, activating zoom capabilities to collect high-resolution facial images will imply temporary loss of "pan" capability which can capture potential events (albeit at lower resolutions) elsewhere in the coverage area of the camera sensor.
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